Fast and sensitive supercritical fluid chromatography - tandem mass spectrometry multi-class screening method for the determination of doping agents in urine
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- 作者：Lucie Nová ; ková ; a ; Vincent Desfontaineb ; Federico Ponzettoc ; Raul Nicolic ; Martial Saugyc ; Jean-Luc Veutheyb ; Davy Guillarmeb ; davy.guillarme@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Doping agents ; Urine ; Supercritical fluid chromatography ; Tandem mass spectrometry ; Supported liquid extraction ; Steroids
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：915
- 期：Complete
- 页码：102-110
- 全文大小：1824 K
文摘
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A high throughput UHPSFC-MS/MS method was developed for screening several classes of doping agents in urine.
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Supported liquid extraction in 48-well plate format was successfully applied to extract the doping agents from urine samples.
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Good extraction recoveries and reasonable matrix effects were observed for the whole set of doping agents.
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The method exhibited very low LODs, below the Minimum Required Performance Levels, for most of the 100 compounds.