Postoperative Serum Concentrations of High Mobility Group Box Chromosomal Protein-1 Correlates to the Duration of SIRS and Pulmonary Dysfunction Following Gastrointestinal Surgery

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• 作者：Risa Takahata M.D.^* ; Satoshi Ono M.D.^† ; ; ^{satoshi@ndmc.ac.jp"" rel=""nofollow} ; Hironori Tsujimoto M.D.^* ; Shuichi Hiraki M.D.^* ; Akifumi Kimura M.D.^* ; Manabu Kinoshita M.D.^Ȃ1 ; ; Hiromi Miyazaki Ph.D.^† ; ; Daizoh Saitoh M.D.^† ; ; Kazuo Hase M.D.^*
• 关键词：HMGB-1 ; SIRS ; pulmonary dysfunction ; gastrointestinal surgery
• 刊名：Journal of Surgical Research
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：170
• 期：1
• 页码：e135-e140
• 全文大小：516 K

文摘

Objective

To clarify the time course of changes in the serum HMGB-1 concentrations in patients undergoing major gastrointestinal surgery, and to investigate whether the serum HMGB-1 levels correlate with the postoperative clinical course of the patients.

Methods

Twenty-eight patients with alimentary tract carcinoma who underwent elective gastrointestinal surgery were enrolled in this study. The correlation between the serum HMGB-1 levels and the postoperative clinical course were evaluated.

Results

Serum HMGB-1 concentrations in patients who underwent surgery for gastrointestinal cancer increased gradually during postoperative days, and reached peak concentrations on postoperative day 3 (POD3). There was a statistically significant positive correlation between the serum HMGB-1 levels on POD3 or POD5 and the duration of SIRS (r = 0.68, P < 0.001, r = 0.45, P < 0.05, respectively). A significantly positive correlation was found between the serum HMGB-1 levels on POD3 or POD5 and the heart rates on POD3 or POD5. Furthermore, there was a negative correlation between the serum HMGB-1 levels and PaO2/FiO2 ratio on POD3.

Conclusions

Serum HMGB-1 levels increase after major gastrointestinal surgery, and the serum peak HMGB-1 levels correlate with the duration of SIRS and postoperative pulmonary dysfunction.