Adipose circadian rhythms: Translating cellular and animal studies to human physiology

详细信息    查看全文

• 作者：Jonathan D. Johnston ; ^{j.johnston@surrey.ac.uk}
• 关键词：Circadian ; Clock gene ; Adipose ; Adipocyte ; Metabolism ; Translational
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2012
• 出版时间：5 February 2012
• 年：2012
• 卷：349
• 期：1
• 页码：45-50
• 全文大小：189 K

文摘

Emerging links between circadian rhythms and metabolism promise much for the understanding of metabolic physiology and pathophysiology, in which white adipose tissue (WAT) plays a prominent role. Many WAT endocrine molecules, termed adipokines, display rhythmic plasma concentration. Moreover, similar to most other tissues, WAT exhibits widespread 24-h variation in gene expression, with approximately 20 % of the murine adipose transcriptome estimated to undergo daily variation.

A major limitation to human chronobiology research is the availability of physiologically defined peripheral tissues. To date most analyses of in vivo human peripheral clocks has been limited to blood leucocytes. However, subcutaneous adipose tissue represents a novel opportunity to study peripheral molecular rhythms that are of clearly defined metabolic relevance.

This review summarises basic concepts of circadian and metabolic physiology before then comparing alternative protocols used to analyse the rhythmic properties of human adipose tissue.