Germline ablation of dermatan-4O-sulfotransferase1 reduces regeneration after mouse spinal cord injury
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- 作者：S. Rosta ; &dagger ; ; N. Akyü ; za ; &dagger ; ; T. Martinovica ; b ; T. Huckhagela ; I. Jakovcevskia ; c ; d ; igor.jakovcevski@dzne.de" class="auth_mail" title="E-mail the corresponding author ; M. Schachnera ; e ; f ; schachner@stu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ChABC ; chondroitinase ABC ; ChAC ; chondroitinase AC ; ChAT ; choline acetyltransferase ; ChB ; chondroitinase B ; Chst14 ; carbohydrate sulfotransferase 14 also known as dermatan-4O-sulfotransferase1 ; CS ; chondroitin sulfate ; CSPG ; chondroitin sulfate proteoglycan ; DS ; dermatan sulfate ; DSPG ; dermatan sulfate proteoglycan ; GFAP ; glial fibrillary acidic protein ; NG2 ; new glue 2 also known as chondroitin sulfate proteoglycan 4 (CSPG4) ; MBP ; myelin basic protein ; SCI ; spinal cord injury ; TH ; tyrosine hydr
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：312
- 期：Complete
- 页码：74-85
- 全文大小：3285 K
文摘
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We developed mice deficient in Chst14, pivotal enzyme by generation of dermatan sulfate.
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We performed spinal cord injury in Chst14-deficient mice (Chst14−/−).
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We observed reduced locomotor recovery after spinal cord injury in Chst14−/− versus Chst14+/+ mice.
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Chst14 ablation slightly reduced axonal regeneration, and had no effect on glial scar formation.