Genetic variants in microRNA-146a (C > G) and microRNA-1269b (G > C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer
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- 作者：Hung-Chih Chena ; b ; 1 ; Yu-Kai Tsengc ; d ; 2 ; Chao-Chuan Chie ; 3 ; Yu-Hung Chena ; 4 ; Cheng-Mei Yanga ; b ; 5 ; Sin-Jhih Huangf ; 6 ; Yi-Cheng Leef ; g ; 7 ; Huei-Han Liouf ; 8 ; Kuo-Wang Tsaif ; h ; 9 ; kwtsai@vghks.gov.tw" class="auth_mail" title="E-mail the corresponding author ; Luo-Ping Gerf ; i ; 10 ; lpger@vghks.gov.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oral cancer ; Pharyngeal cancer ; Polymorphisms ; miR-146a ; miR-1269b ; Risk
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：21-32
- 全文大小：562 K
文摘
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To the best of our knowledge, miR-1269b polymorphism has never been investigated in any premalignant lesions or cancers.
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This is the first study to find that the genetic variants of miR-1269b are associated with a decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer.