Patients with chronic kidney disease (CKD) have cardiac abnormalities, and left ventricular systolic dysfunction (LVSD) is a common manifestation.

p-Cresylsulfate (PCS), a protein-bound uraemic retention solute, is known to cause endothelial dysfunction and possibly plays a role in coronary atherosclerosis.

Left atrium diameter, left ventricular mass index, end diastolic interventricular septal thickness, left ventricular end-systolic diameter, left ventricular end-systolic volume, stroke volume, left ventricular end-systolic volume index, left ventricular ejection fraction, and the interventricular septum/posterior wall of the left ventricle were independently associated with total PCS.

Higher total PCS, CKD, or both were independently associated with LVSD.

High serum levels of total PCS or CKD, or both, represent an increased risk of impaired LV systolic function in stable angina patients.