Dendritic cells transfected with indoleamine 2,3-dioxygenase gene suppressed acute rejection of cardiac allograft
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- 作者：Chuan Li lichuan1980@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Tong Liu liutonga@126.com" class="auth_mail" title="E-mail the corresponding author ; Na Zhao nasy3367@126.com" class="auth_mail" title="E-mail the corresponding author ; Liwei Zhu zhuliwei0804@126.com" class="auth_mail" title="E-mail the corresponding author ; Pengzhi Wang wangpz2009@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Xiangchen Dai ; mzzlee@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Indoleamine 2 ; 3-dioxygenase ; Dendritic cells ; Cardiac transplantation ; Rejection ; Immunological tolerance
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：31-38
- 全文大小：1327 K
文摘
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IDO gene was actively expressed in DCs after transfection by adenovirus vector.
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IDO-positive DCs could suppress T cell proliferation and induce T cell apoptosis in vitro.
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IDO overexpression in DC transfer into the recipients attenuates acute allograft rejection.
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IDO-positive DCs induce T cell apoptosis and polarize cytokine shift toward Th2-dominant response in vivo.