Different effects of surfactant and inhaled nitric oxide in modulation of inflammatory injury in ventilated piglet lungs

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• 作者：Zhu ; Yourong ; Guo ; Chunbao ; Cao ; Lei ; Gong ; Xiaohui ; Wang ; Chuanqing ; Sun ; Bo
• 关键词：Acute lung injury ; Pulmonary surfactant ; Nitric oxide ; Nuclear factor-κ ; B
• 刊名：Pulmonary Pharmacology & Therapeutics
• 出版年：2005
• 出版时间：August, 2005
• 年：2005
• 卷：18
• 期：4
• 页码：303-313
• 全文大小：373 K

文摘

Septic acute lung injury (ALI) causes high morbidity and mortality in intensive care service as a result of biotrauma and dysfunction in the lungs and other organ systems. We hypothesized that surfactant and/or inhaled nitric oxide (iNO) may have different effects in modulation of inflammatory injury in septic ALI. Twenty-four healthy, 6–9kg piglets were anesthetized, and intraperitoneally injected with Escherichia coli, followed by a low tidal volume ventilation until sepsis and ALI developed within 4–6h. They were then randomly treated in groups (n