- 作者：Sai Prasad Gopal ; MD ; Vijay Narayan Tiwari ; MD ; PhD ; Amy L. Veenstra ; MA ; Ajay Kumar ; MD ; PhD ; Michael Behen ; PhD ; Harry T. Chugani ; MD ; Senthil K. Sundaram ; MD ; susundaram@pet.wayne.edu
- 关键词：AP ; Anterioposterior ; AF ; Arcuate fasciculus ; AS ; Angelman syndrome ; DD ; Developmental delay ; DTI ; Diffusion tensor imaging ; ML ; Mediolateral ; TD ; Typically developing
- 刊名：The Journal of Pediatrics
- 出版年：2012
- 出版时间：January, 2012
- 年：2012
- 卷：160
- 期：1
- 页码：147-151
- 全文大小：369 K
Objective
To investigate whether abnormal regional white matter architecture in the perisylvian region could be used as an easy and sensitive quantitative method to demonstrate language pathway abnormalities in children with developmental delay (DD).Study design
We performed diffusion tensor imaging in 15 DD subjects (age, 61.1 ¡À 20.9 months) and 15 age-matched typically developing (TD) children (age, 68.4 ¡À 19.2 months). With diffusion tensor imaging color-coded orientation maps, we quantified the fraction of fibers in the perisylvian region that are oriented in anteroposterior (AP) and mediolateral (ML) directions, and their ratio (AP/ML) was calculated.
Results
The AP/ML ratio was more sensitive than tractography in characterizing perisylvian regional abnormalities in DD children. The AP/ML ratio of the left perisylvian region was significantly lower in DD children compared with TD children (P = .03). The ML component of bilateral perisylvian regions was significantly higher in DD children compared with TD children (P = .01 [left] and P = .004 [right]). No significant difference was found in the AP component in the two groups. A significant negative correlation of the left ML component with Vineland communication skills was observed (r = ?0.657, P = .011).
Conclusions
The AP/ML ratio appears to be a sensitive indicator of regional white matter architectural abnormalities in the perisylvian region of DD children.