Postnatal development of synapses in rat medial nucleus of the trapezoid body.

详细信息    查看全文

• 作者：Chuhma ; Nao ; Ohmori ; Harunori
• 刊名：Neuroscience Research
• 出版年：2001
• 出版时间：December, 2001
• 年：2001
• 卷：25
• 期：Supplement 1
• 页码：S44
• 全文大小：68.8 K

文摘

Slices of medial nucleus of the trapezoid body were prepared form postnatal rats ranging from 4 to 11 days old and excitatory post synaptic currents (EPSC) were recorded. On 4 or 5 postnatal days (P4 or P5), EPSCs were small and showed multiple peaks. After P8, all the recorded EPSCs were large and had a single-peak. We studied postnatal development of presynaptic K⁺ channel by the use of K⁺ channel blocker. Before P8, 0.5mM 4AP enhansed synaptic transmittion, however after P10, it depressed the transmittion. This suggests that the current through the 4AP-sensitive K⁺ channel dominates during development between P4 and P11.