DNMT3A R882 Mutation with FLT3-ITD Positivity Is an Extremely Poor Prognostic Factor in Patients with Normal-Karyotype Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation
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- 作者：Jae-Sook Ahn1 ; Hyeoung-Joon Kim1 ; hjoonk@chonnam.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Yeo-Kyeoung Kim1 ; Seun-Shin Lee1 ; Sung-Hoon Jung1 ; Deok-Hwan Yang1 ; Je-Jung Lee1 ; Nan Young Kim2 ; Seung Hyun Choi2 ; Chul Won Jung3 ; Jun-Ho Jang3 ; Hee Je Kim4 ; Joon Ho Moon5 ; Sang Kyun Sohn5 ; Jong-Ho Won6 ; Sung-Hyun Kim7 ; Dennis Dong Hwan Kim8
- 关键词：Acute myeloid leukemia ; TET2 ; IDH1/2 ; DNMT3A ; Allogeneic hematopoietic cell transplantation ; Normal karyotype
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：22
- 期：1
- 页码：61-70
- 全文大小：1171 K
文摘
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DNMT3A R882 mutation, particularly when accompanied by FLT3-ITD positivity, had a significant prognostic impact on survival and relapse rates in patients with NK-AML after allogeneic hematopoietic cell transplantation.
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In contrast, non–R882 DNMT3A mutations did not influence transplantation outcome.
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No differences in overall survival, event-free survival, or relapse incidence were observed in patients with TET2 mutation or IDH1/2 mutation after allogeneic hematopoietic cell transplantation.