Development of a novel l-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailability
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- 作者：Dong Shik Kima ; 1 ; Dong Wuk Kima ; 1 ; Kyeong Soo Kima ; Jong Seo Choia ; Youn Gee Seob ; Yu Seok Younc ; Kyung Taek Ohd ; Chul Soon Yongb ; Jong Oh Kimb ; jongohkim@yu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; jongohkim1@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sung Giu Jina ; sklover777@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Han-Gon Choia ; hangon@hanyang.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：l-sulpiride ; Quaternary microcapsule ; d-α-tocopheryl polyethylene glycol 1000 succinate ; Oral absorption ; Administered drug dose
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：250-257
- 全文大小：1200 K
文摘
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l-sulpiride loaded quaternary microcapsule (QMC) was prepared by solvent evaporation technique.
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From DSC and PXRD results, the drugs in the QMCs were in the amorphous form.
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l-sulpiride loaded QMC improved the solubility, release and oral bioavailability than drug alone.
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TPGS greatly improved the bioavailability of drug as the administered drug doses were increased.
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TPGS played an important role in the enhanced oral bioavailability of drug.