Epigenetic modification of miR-10a regulates renal damage by targeting CREB1 in type 2 diabetes mellitus
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- 作者：Qun Shan shanp@jsnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guihong Zheng ghzhengsd@jsnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Aihua Zhu ahzhu@jsnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Li Cao 948113717@qq.com" class="auth_mail" title="E-mail the corresponding author ; Jun Lu lu-jun75@163.com" class="auth_mail" title="E-mail the corresponding author ; Dongmei Wu wdm8610@jsnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; ZiFeng Zhang zhangzifengsuper@jsnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shaohua Fan fshfly@126.com" class="auth_mail" title="E-mail the corresponding author ; Chunhui Sun 306484866@qq.com" class="auth_mail" title="E-mail the corresponding author ; Bin Hu hubin@jsnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yuanlin Zheng ; ylzheng@jsnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 2 diabetes ; Kidney damage ; miR-10a ; CREB1 ; HDAC3
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：306
- 期：Complete
- 页码：134-143
- 全文大小：1895 K
文摘
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Diabetes induces the decrease of miR-10a level in the kidney.
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MiR-10a overexpression improves kidney damage of diabetes.
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MiR-10a targeting CREB1/FN implicates in kidney impairment.
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HDAC3 regulates kidney damage by epigenetically modulating miR-10a.