Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect

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• 作者：Chiang-Wen Lee ; Horng-Huey Ko ; Chun-Ching Lin ; Chee-Yin Chai ; Wan-Tzu Chen ; Feng-Lin Yen
• 关键词：Artocarpin ; Ultraviolet B irradiation ; Histopathological changes ; Antioxidant ; Anti-inflammation
• 刊名：Food and Chemical Toxicology
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：60
• 期：Complete
• 页码：123-129
• 全文大小：1164 K

文摘

Artocarpin, a prenylated flavonoid isolated from an agricultural plant Artocarpus communis, has been documented to possess anti-inflammation and anticancer activities. As oxidative stress and inflammation promote the development of ultraviolet B (UVB) irradiation-induced photodamage, the aim of the present study was to evaluate the photoprotective effect of artocarpin on UVB-induced skin damage in hairless mice. Artocarpin at a topical dose of 0.05 % and 0.1 % showed a significant photoprotective effect by decreasing histopathological changes, such as desquamation, epidermal thicken and sunburn cell formation, but 0.1 % of artocarpin administration did not show better effect. Regarding the antioxidant activities, artocarpin exhibited a significant effect (P < 0.05) by decreasing levels of reactive species oxygen and lipid peroxidation. In addition, artocarpin can significantdecrease the level of tumor necrosis factor-¦Á and interleukin-1¦Â for downregulating the inflammation protein, including the synthesis of cytosolic phospholipase A2 and cyclooxygenase-2 (P < 0.05). In conclusion, these data suggest that artocarpin can prevent skin damage from UVB irradiation-induced photodamage in hairless mice and this is likely mediated through its antioxidant and anti-inflammation mechanisms. Therefore, we suggested that artocarpin could be a useful photoprotective agent in medicine and/or cosmetics.