Peritumoral ductular reaction is related to nuclear translocation of β-catenin in hepatocellular carcinoma
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- 作者：Xiaobo Caia ; 1 ; Feng Lib ; 1 ; QingQing Zhanga ; Mingyi Xua ; Ying Qua ; Xinjian Wana ; Chunfang Gaoc ; Gaocf1115@163.com" class="auth_mail" title="E-mail the corresponding author ; Lungen Lua ; Lungenlu1965@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatocellular carcinoma ; Peritumoral ductular reaction ; β-Catenin
- 刊名：Biomedicine & Pharmacotherapy
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：76
- 期：Complete
- 页码：11-16
- 全文大小：2126 K
文摘
Increased peritumoral ductular reaction (DR) is related to poor prognosis in hepatocellular carcinoma (HCC) but the mechanism is unclear. Nuclear translocation of β-catenin is correlated with HCC metastasis and recurrence. Thus, we aim to explore whether there is a relationship between peritumoral DR and tumoral nuclear translocation of β-catenin in HCC. Hepatitis B virus (HBV)-related HCC patients (n = 120) were enrolled into this study from January 2003 to December 2007. Clinicopathological variables were collected and immunohistochemistry staining for cytokeratin 19 (CK19), proliferating cell nuclear antigen (PCNA), β-catenin, phosphorylated-Smad2 (PSmad2) and transforming growth factor-β1 (TGF-β1) were performed in tumor and/or peritumor liver tissues. Peritumoral DR is significantly correlated with local inflammation (P < 0.001), fibrosis (P < 0.001), tumor size (P = 0.006) and CK19 expression in the tumor (P = 0.005). More patients with peritumoral DR had nuclear accumulation of β-catenin than patients with mild peritumoral DR (37.50% vs. 14. 58%, P = 0.011). HCCs in the obvious DR group had stronger expression of PSmad2 than that in the mild DR group, and patients with nuclear translocation of β-catenin also had higher PSmad2 expression. In conclusion, increased peritumoral DR is related to tumoral nuclear translocation of β-catenin in HCC and enhanced action of TGF-β1 signaling may be involved in this relationship.