Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology

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• 作者：Jin Woo Lee¹ ; Eun Jin Mo¹ ; Ji Eun Choi¹ ; Yang Hee Jo¹ ; Hari Jang¹ ; Ji Yeon Jeong¹ ; Qinghao Jin¹ ; Hee Nam Chung² ; Bang Yeon Hwang¹ ; Mi Kyeong Lee¹ ; ^{mklee@chungbuk.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：antioxidant activity ; extraction conditions ; extraction yield ; optimization ; Panax ginseng (Korean Red Ginseng)
• 刊名：Journal of Ginseng Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：40
• 期：3
• 页码：229-236
• 全文大小：1087 K

文摘

Extraction conditions greatly affect composition, as well as biological activity. Therefore, optimization is essential for maximum efficacy.

Methods

Korean Red Ginseng (KRG) was extracted under different conditions and antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content evaluated. Optimized extraction conditions were suggested using response surface methodology for maximum antioxidant activity and extraction yield.

Results

Analysis of KRG extraction conditions using response surface methodology showed a good fit of experimental data as demonstrated by regression analysis. Among extraction factors, such as extraction solvent and extraction time and temperature, ethanol concentration greatly affected antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content. The optimal conditions for maximum antioxidant activity and extraction yield were an ethanol concentration of 48.8%, an extraction time 73.3 min, and an extraction temperature of 90°C. The antioxidant activity and extraction yield under optimal conditions were 43.7% and 23.2% of dried KRG, respectively.

Conclusion

Ethanol concentration is an important extraction factor for KRG antioxidant activity and extraction yield. Optimized extraction conditions provide useful economic advantages in KRG development for functional products.