New insights after the first 1000 liver transplantations at The University of Hong Kong

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• 作者：See Ching Chan^a ; ^{seechingchan@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Tan To Cheung^a ; Albert C.Y. Chan^a ; Kenneth S.H. Chok^a ; William W. Sharr^a ; James Y.Y. Fung^b ; Chi Leung Liu^a ; Sheung Tat Fan^a ; Chung Mau Lo^a
• 关键词：deceased donor liver transplantation ; experience ; living donor liver transplantation
• 刊名：Asian Journal of Surgery
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：39
• 期：4
• 页码：202-210
• 全文大小：983 K

文摘

One thousand liver transplantations have been performed at the only liver transplant center in Hong Kong over a period of 22 years, which covered the formative period of living donor liver transplantation. These 1000 transplantations, which marked the journey of liver transplantation from development to maturation at the center, should be educational. This research was to study the experience and to reflect on the importance of technical innovations and case selection.

Methods

The first 1000 liver transplantations were studied. Key technical innovations and surgical therapeutics were described. Recipient survival including hospital mortality was analyzed. Recipient survival comparison was made for deceased donor liver transplantation and living donor liver transplantation indicated by hepatocellular carcinoma and other diseases.

Results

Among the 1000 transplantations, 418 used deceased donor grafts and 582 used living donor grafts. With the accumulation of experience, hospital mortality improved to < 2% in the past 2 years. In the treatment of diseases other than hepatocellular carcinoma, living donor liver transplantation was superior to deceased donor liver transplantation, with a 10-year recipient survival around 90%.

Conclusion

Transplant outcomes have been improving consistently over the series, with a very low hospital mortality and a predictably high long-term survival.