A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo[2,1-f][1,2,4] triazin-4(3H)-ones

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• 作者：Yanhong Chen ; Haoyue Xiang ; Cun Tan ; Yuyuan Xie ; Chunhao Yang ; ^{chyang@mail.shcnc.ac.cn} ; ^{chyang@simm.ac.cn}
• 关键词：Tandem annulation ; Cupric chloride ; 1-Amino-1H-pyrrole-2-amides ; Privileged structure ; Pyrrolo[2 ; 1-f][1 ; 2 ; 4]triazin-4(3H)-ones
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：1 April, 2013
• 年：2013
• 卷：69
• 期：13
• 页码：2714-2719
• 全文大小：341 K

文摘

An efficient tandem method for the annulation of 1-amino-1H-pyrrole-2-amides with various substituted benzaldehydes, heteroaryl aldehydes, alkyl aldehydes or even acetals, promoted by cupric chloride, to synthesize 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones is reported. This approach provides a useful method for constructing the privileged structure in medicinal chemistry. Electron-donating groups on both partners could accelerate the reaction.