Controlled loading and release of methylene blue in layer-by-layer assembled polyelectrolyte films

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• 作者：Chunrui Ding ; Shimei Xu ; Jide Wang ; Yang Liu ; Peng Chen ; Shun Feng ; ^{fengshun@xju.edu.cn}
• 关键词：Controlled loading and release ; Layer-by-layer ; Multilayer films ; Reversible loading and release
• 刊名：Materials Science and Engineering: C
• 出版年：2012
• 出版时间：1 May, 2012
• 年：2012
• 卷：32
• 期：4
• 页码：670-673
• 全文大小：358 K

文摘

The layer-by-layer (LbL) assembled multilayer films are widely used in the biomedical field for the controlled drug delivery. Here, multilayer films were assembled by LbL technique through alternating deposition of poly(diallyldimethylammonium chloride) (PDDA) and poly(acrylic acid) (PAA) on glass slides. Methylene blue (MB) was used as a model drug to investigate the loading and release ability of the multilayer films. The result showed that the loading rate and loading amount of MB were greatly influenced by ionic strength and pH value of the dye solution, and the release rate of MB was also controlled both by ionic strength and pH value of immersing solution. The result also testified that the films had good reversibility of drug loading and release. It suggested that the PDDA/PAA multilayer films had a potential application in drug delivery, especially in drug burst release.