Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of聽head and neck squamous cell carcinoma
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- 作者：Pilar Bayoa ; b ; 1 ; pilarbz@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Adriana Jouc ; d ; e ; 1 ; a.jou@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Albrecht Stenzingerf ; albrecht.stenzinger@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Chunxuan Shaog ; c.shao@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Madeleine Grossc ; d ; MadeleineGross@gmx.de" class="auth_mail" title="E-mail the corresponding author ; Alexandra Jensenh ; alexandra.jensen@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Niels Grabei ; j ; niels.grabe@bioquant.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Christel Herold Mendek ; l ; h.mende@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Pantelis Varvaki Radose ; pantelis@ufrgs.br" class="auth_mail" title="E-mail the corresponding author ; Juergen Debush ; juergen.debus@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Wilko Weichertf ; wilko.weichert@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Peter K. Plinkerta ; peter_plinkert@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Peter Lichterd ; Peter.Lichter@Dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Kolja Freierc ; kolja.freier@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Jochen Hessa ; b ; j.hess@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cell motility ; Gene expression profiling ; Immunohistochemistry ; Prognostic biomarker ; Tissue microarray
- 刊名：Molecular Oncology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：9
- 期：8
- 页码：1704-1719
- 全文大小：4237 K
文摘
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Loss of SOX2 function promotes cell motility of head and neck cancer cells.
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Tumor cells exhibit inverse expression of SOX2 and vimentin both in vitro and in vivo.
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Vimentin down-regulation partially reverts accelerated motility after SOX2 silencing.
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Low SOX2 protein levels are correlated with patient poor clinical outcome.
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SOX2 serves as an independent prognostic biomarker for treatment failure.