Lon protease and eiF2α are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells
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- 作者：Savania Nagiahb ; 208509769@ukzn.stu.az.za" class="auth_mail" title="E-mail the corresponding author ; Alisa Phulukdareec ; 1 ; phulukdaree@up.ac.za" class="auth_mail" title="E-mail the corresponding author ; Anil A. Chuturgoona ; b ; CHUTUR@ukzn.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：NRTI ; Lon ; SIRT3 ; eIF2α ; Mitochondrial stress
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：252
- 期：Complete
- 页码：82-86
- 全文大小：517 K
文摘
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Antiretroviral (ARV) drugs cause oxidative stress and affect protein homeostasis.
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Lon, SIRT3 and HSP60 are required for mitochondrial protein maintenance.
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ER stress protein eIF2α is linked to Lon and HSP60 recruitment.
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Acute ARV exposure induce ATP-dependent stress proteins (Lon, HSP60, eIF2α).
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SIRT3 is NAD+ dependent and is sustained in chronic ARV exposure in HepG2 cells.