Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b
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- 作者：Anil A. Chuturgoon ; chutur@ukzn.ac.za" class="auth_mail ; Alisa Phulukdaree ; Devapregasan Moodley1
- 关键词：Fumonisin B1 ; MicroRNA (miR)-27b ; Cytochrome P 450 (CYP1B1) ; Liver cancer ; HepG2 cells
- 刊名：Toxicology Letters
- 出版年：16 May 2014
- 年：2014
- 卷：227
- 期：1
- 页码：50-55
- 全文大小：1035 K
文摘
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Fumonisin B1 significantly downregulates miR27b in HepG2 cells.
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FB1, significantly upregulates CYP1B1 mRNA and protein expression in HepG2 cells.
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CYP1B1 is post-transcriptionally regulated by miR-27b after HepG2 exposure to FB1.