Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells
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- 作者：Janina Dosea ; dose@foodsci.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author ; j.dose@ikmb.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author ; Almut Nebelb ; a.nebel@mucosa.de" class="auth_mail" title="E-mail the corresponding author ; Stefanie Piegholdta ; piegholdt@foodsci.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author ; Gerald Rimbacha ; rimbach@foodsci.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author ; Patricia Huebbea ; huebbe@foodsci.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; APOE ; apolipoprotein E ; ATP ; adenosine triphosphate ; ATP5A1 ; ATP synthase subunit alpha ; mitochondrial ; B2M ; beta-2 microglobulin ; BAX ; BCL2-associated X protein ; BCL2 ; B-cell leukemia/lymphoma 2 ; BiP ; binding immunoglobulin protein ; BSO ; D ; L-buthionine sulfoximine ; COX4I1 ; cytochrome c oxidase subunit 4 isoform 1 ; CYCS ; cytochrome c ; somatic ; DDIT3 ; DNA-damage-inducible transcript 3 ; EEF2 ; eukaryotic translation elongation factor 2 ; ER ; endoplasmic reticulum ; FIS1 ; fiss
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：264-272
- 全文大小：738 K
文摘
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Overall, rather low influence of the APOE genotype on hepatic stress response; APOE4 vs. APOE3 was associated with…
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Lower chymotrypsin-like and higher trypsin-like proteasome activity.
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Trendwise higher levels of protein carbonyls.
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Lower Atp5a1 gene expression and correspondingly lower ATP levels in hepatocytes.
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Similar transcript and protein levels of key proteins of major cellular stress pathways.