Comparative cytotoxicity studies of carbon-encapsulated iron nanoparticles in murine glioma cells
详细信息 查看全文
- 作者：Ireneusz P. Grudzinskia ; ireneusz.grudzinski@wum.edu.pl" class="auth_mail ; Michal Bystrzejewskib ; Monika A. Cywinskaa ; Anita Kosmidera ; Magdalena Poplawskac ; Andrzej Cieszanowskid ; Zbigniew Fijaleke ; Agnieszka Ostrowskaf
- 关键词：Carbon encapsulates ; Iron nanoparticles ; Surface functionalization ; Cytotoxicity ; Murine glioma cells (GL261)
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：1 May 2014
- 年：2014
- 卷：117
- 期：Complete
- 页码：135-143
- 全文大小：2491 K
文摘
- •
The cytotoxic effects of carbon-encapsulated iron nanoparticles (CEINs) were examined in murine glioma cells (GL261).
- •
These nanoparticles induce mitochondrial and cell membrane targeted toxicities.
- •
They also affect the cell cycle progression in the S and G2/M phases and mitochondrial membrane potentials.
- •
The CEIN samples, especially the raw nanoparticles, promote some pro-apoptotic events.
- •
The doses of CEINs administered and especially the surface composition of these nanoparticles are critical determinants of different cytotoxic responses in GL261 cells.