Evaluation of the Tobacco Heating System 2.2. Part 8: 5-Day randomized reduced exposure clinical study in Poland
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- 作者：Christelle Haziza ; Christelle.Haziza@pmi.com ; Guillaume de La Bourdonnaye ; Dimitra Skiada ; Jacek Ancerewicz ; Gizelle Baker ; Patrick Picavet ; Frank Lü ; dicke
- 关键词：Tobacco heating system ; Conventional cigarettes ; Smoking abstinence ; Randomized study ; Biomarkers of exposure ; Harmful and potentially harmful constituents
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：30 November 2016
- 年：2016
- 卷：81
- 期：supp_S2
- 页码：S139-S150
- 全文大小：896 K
- 卷排序：81
文摘
We compared the Tobacco Heating System (THS) 2.2 and conventional cigarettes (CCs). Biomarkers of exposure are reduced upon THS 2.2 use close to smoking abstinence. Subjects adapt quickly to THS 2.2 while maintaining their desired nicotine level. Reduction in urge-to-smoke was comparable between THS 2.2 and CCs. THS 2.2 was perceived as less rewarding than CCs.