Chiral ligand-exchange chromatography with Cinchona alkaloids. Exploring experimental conditions for enantioseparation of α-amino acids
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- 作者：Romina N. Echevarrí ; aa ; Carlos A. Francab ; Marcos Tascona ; Cecilia B. Castellsa ; Sonia Keunchkariana ; sonja@quimica.unlp.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chiral ligand-exchange chromatography ; Cinchona alkaloids ; α-Amino acids ; Molecular geometry
- 刊名：Microchemical Journal
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：104-110
- 全文大小：733 K
文摘
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Racemic natural amino acids were resolved using chiral ligand-exchange chromatography (CLEC).
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Quinidine and different divalent cations were used as chiral mobile phase additives under CLEC.
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Experimental conditions were first time systematically studied for these chromatographic systems.
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Molecular structure for the diastereomeric complexes was proposed based on the molecular dynamic approach.