Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression
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- 作者：Yuliya V. Katlinskaya1 ; 8 ; Kanstantsin V. Katlinski1 ; 8 ; Qiujing Yu1 ; Angelica Ortiz1 ; Daniel P. Beiting2 ; Angela Brice2 ; Diwakar Davar3 ; Cindy Sanders3 ; John M. Kirkwood3 ; Hallgeir Rui4 ; Xiaowei Xu5 ; Constantinos Koumenis6 ; J. Alan Diehl7 ; Serge Y. Fuchs1 ; syfuchs@vet.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：melanoma ; type I interferon ; interferon receptor ; senescence ; BRAF ; metastasis
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：15
- 期：1
- 页码：171-180
- 全文大小：3115 K
文摘
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Type I IFNs contribute to development of the oncogene-induced senescence
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Suppression of IFN signaling suffices to induce melanoma by activated Braf
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IFN signaling in melanocytes and other cell types counteracts melanoma development
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Downregulation of IFN receptor IFNAR1 promotes melanoma development and progression