Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer’s-like dementia: Involvement of acetylcholinesterase and cell death

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• 作者：Juliana Sorraila de Oliveira^a ; Fá ; tima Husein Abdalla ; Ph.D^b ; ^{faha.biomed@hotmail.com} ; Guilherme Lopes Dornelles^c ; Stephen Adeniyi Adefegha^b ; Taí ; s Vidal Palma^a ; Cristiane Signor^d ; Jamile da Silva Bernardi^b ; Jucimara Baldissarelli^b ; Luana Sué ; ling Lenz^a ; Luana Pereira Magni^a ; Maribel Antonello Rubin^d ; Micheli Mainardi Pillat^a ; Cinthia Melazzo de Andrade ; Ph.D^c ; ^{cmelazzomazzanti@gmail.com}
• 关键词：Neuroprotection ; Alzheimer&rsquo ; s disease ; Streptozotocin ; Cholinergic system ; Berberine ; Behavioral tests
• 刊名：NeuroToxicology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：241-250
• 全文大小：1389 K
• 卷排序：57

文摘

ICV-STZ impaired memory and axiogenic behavior. Berberine prevented the ICV-STZ induced improvement of memory and axiogenic behavior. BRB prevented the increase of AChE activity and cell death effect of ICV-STZ.