MR angiography findings in infants with neonatal arterial ischemic stroke in the middle cerebral artery territory: A prospective study using circle of Willis MR angiography

详细信息    查看全文

• 作者：Bé ; atrice Husson^a ; Lucie Hertz-Pannier^b ; Catherine Adamsbaum^c ; ^{adamsbaum.catherine@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Cyrille Renaud^d ; Emilie Presles^e ; Mickael Dinomais^f ; Manoelle Kossorotoff^g ; Pierre Landrieu^h ; Sté ; phane Chabrier^d ; ^e
• 关键词：Neonatal stroke ; Cerebral palsy ; Magnetic resonance angiography ; Magnetic resonance imaging ; Occlusion
• 刊名：European Journal of Radiology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：85
• 期：7
• 页码：1329-1335
• 全文大小：1389 K

文摘

Neonatal arterial ischemic stroke (NAIS) results from a focal disruption of the blood flow in a cerebral artery by a not well understood mechanism. Our objective is to describe the acute MRangiography (MRA) findings in infants with an NAIS in the middle cerebral artery (MCA) territory and correlate them with early parenchymal infarcts and motor outcome.

Methods

Among one hundred prospectively followed neonates with NAIS, we studied thirty-seven patients with an MCA infarct explored with circle of Willis MRA. MCA flow characteristics were documented, along with infarct location/extent and motor outcome at age 7 years.

Results

Twenty-three (62%) of the children showed arterial changes, all ipsilateral to the NAIS, with occlusion in six, thrombus-type flow defect in nine, and unilateral increased flow in enlarged insular arteries in the remaining eight. There was a statistically significant correlation between parenchymal and arterial MR findings (p = 0.0002). A normal MRA had a negative predictive value of 100% (95% CI: 76.8-100) in ruling out a main branch infarct. Patients with abnormal MRA tended to be at increased risk for cerebral palsy (OR = 3.1). Occlusion was associated with a worse outcome (p = 0.04).

Interpretation

MRangiography shows arterial abnormalities suggesting that embolism is a frequent cause of NAIS.