Gimme a complex! Resident mononuclear phagocytes in the kidney as monitors of circulating antigens and immune complexes

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• 作者：Wulf Tonnus¹ ; Christian Hugo² ; Andreas Linkermann¹ ; ² ; ^{andreas.linkermann@uniklinikum-dresden.de}
• 刊名：Kidney International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：91
• 期：2
• 页码：267-269
• 全文大小：661 K
• 卷排序：91

文摘

Over the past decade, researchers have made substantial progress in characterizing a network of mononuclear phagocytes in the kidney, which variously have been referred to as resident macrophages or dendritic cells. Two recent studies, published in Cell and Kidney International, have identified these resident macrophages/dendritic cells as local immune monitors of peritubular capillaries for circulating antigens and immune complexes. These cells appear to represent an early line of defense against circulating infectious particles and immune complexes, but the resulting inflammatory response may also contribute to interstitial inflammation and kidney disease progression.