Reperfusion Correlates and Clinical Outcomes of Right Ventricular Dysfunction in Patients With Inferior ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

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• 作者：Raffaele Piccolo ; MD^a ; Tullio Niglio ; MD^a ; Letizia Spinelli ; MD^a ; Ernesto Capuano ; MD^a ; Teresa Strisciuglio ; MD^a ; Carolina D'Anna ; MD^a ; Stefania De Luca ; MD^a ; Dario Leosco ; MD^c ; Antonio Rapacciuolo ; MD ; PhD^a ; Plinio Cirillo ; MD ; PhD^a ; Eugenio Stabile ; MD ; PhD^a ; Giovanni Esposito ; MD ; PhD^a ; Bruno Trimarco ; MD^a ; Federico Piscione ; MD^b ; Gennaro Galasso ; MD ; PhD^a ; ^{gengalas@unina.it" class="auth_mail}
• 刊名：The American Journal of Cardiology
• 出版年：15 July 2014
• 年：2014
• 卷：114
• 期：2
• 页码：243-249
• 全文大小：351 K

文摘

We evaluated the relation between reperfusion indexes and right ventricular (RV) dysfunction in patients with inferior ST-segment elevation myocardial infarction (STEMI). We included patients with inferior STEMI undergoing percutaneous coronary intervention and right coronary artery as infarct-related artery. Myocardial reperfusion was evaluated by Thrombolysis In Myocardial Infarction (TIMI) flow, TIMI frame count, myocardial blush grade, and ST-segment resolution. RV dysfunction was defined as tricuspid annular plane systolic excursion ≤16 mm in M-mode imaging. RV dysfunction was present in 58 of 141 patients (41.1%) and was more frequent in patients achieving suboptimal postprocedural TIMI flow grade (66.7% vs 36.7%, grades 0 to 2 vs 3, p = 0.01), TIMI frame count (63.2% vs 37.7%, ≥40 vs <40 frames, p = 0.04), and myocardial blush grade (33.3% vs 56.2%, grade 0 or 1 vs 2 or 3, p = 0.001). RV dysfunction rates did not differ according to ST-segment resolution. Patients with RV dysfunction had increased rates of cardiac death (13.2% vs 2.6%, p = 0.03), reinfarction (24.5% vs 10.3%, p = 0.03), and stent thrombosis (22.6% vs 6.4%, p = 0.01) at 2-year follow-up. Postprocedural TIMI flow grade 3 (odds ratio 0.25, 95% confidence interval 0.09 to 0.68, p = 0.007) was the only reperfusion correlate of RV dysfunction at multivariate analysis. In an independent cohort of 84 patients with STEMI, postprocedural TIMI flow grade 3 had a limited sensitivity (52%), with a high specificity (74.5%) and negative predictive value (71%) for excluding RV dysfunction. In conclusion, in patients with inferior STEMI undergoing coronary revascularization, RV dysfunction is associated with a worse long-term prognosis. Postprocedural TIMI flow grade may be a useful tool to predict RV dysfunction.