The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans
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- 作者：Veronica J. Peschansky vpeschansky@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; Chiara Pastori cpastori@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; Zane Zeier zzeier@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; Katya Wentzel k.wentzel1@umiami.edu" class="auth_mail" title="E-mail the corresponding author ; Dmitry Velmeshev dvelmeshev@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; Marco Magistri mmagistri@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; José ; P. Silva jsilva3@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; Claes Wahlestedt ; cwahlestedt@med.miami.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：FXS ; Fragile X syndrome ; FXPOI ; Fragile X-related primary ovarian insufficiency ; FXTAS ; Fragile X-associated tremor/ataxia syndrome ; FMRP ; Fragile X mental retardation protein ; ncRNAs ; Non-coding RNAs ; mRNA ; Messenger RNA ; lncRNAs ; Long non-coding RNAs ; ASD ; Autism spectrum disorder ; hNPCs ; Human neural precursor cells ; EdU ; 5-Ethynyl-2&prime ; -deoxyuridine ; hNS ; Human neurospheres ; H3K4Me3 ; Histone H3 lysine 4 trimethylation ; H3K27Me3 ; Histone H3 lysine 27 trimethylation ; DIV ; Days in vitro
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：49-57
- 全文大小：1176 K
文摘
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FMR4 is a chromatin-associated long noncoding RNA that modulates promoter histone methylation genome-wide.
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FMR4-mediated histone methylation changes are reflected by changes in expression of neurodevelopmental genes.
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Putative FMR4 target genes may be related to its function as a positive regulator of neural precursor cell proliferation.
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Functional, primate-specific long noncoding RNAs such as FMR4 lend complexity to normal biology and disease pathogenesis.