In vitro effects of bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), or VO(dmpp)2, on insulin secretion in pancreatic islets of type 2 diabetic Goto-Kakizaki rats
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- 作者：Julien Pelletiera ; 1 ; Neuza Dominguesb ; 1 ; M.Margarida C.A. Castrob ; c ; Claes-Gö ; ran Ö ; stensona ; claes-goran.ostenson@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 2 diabetes ; VO(dmpp)2 ; Goto-Kakizaki rats ; Insulin secretion ; Pancreatic islets
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：29-34
- 全文大小：641 K
文摘
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Vanadium compounds have been suggested for treatment of type 2 diabetes.
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Oxidovanadium(IV) complex of 1,2-dimethyl-3-hydroxy-4-pyridinonato(dmpp) has been studied.
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VO(dmpp)2, has shown antidiabetic properties by in vitro and in vivo studies.
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Here we show it also improves glucose-induced insulin secretion in GK pancreatic islets.
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This promising result corroborates the use of VO(dmpp)2 for treatment of type 2 diabetes.