- 作者：Rune Rasmussen ; Magnus Claesson ; Sven-Eric Stangerup ; Henrik Roed ; Ib Jarle Christensen ; Per Cay¨¦-Thomasen ; Marianne Juhler
- 关键词：Frationated stereotactic radiotherapy ; Hearing preservation ; Vestibular schwannoma
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 出版时间：1 August, 2012
- 年：2012
- 卷：83
- 期：5
- 页码：e607-e611
- 全文大小：308 K
Objective
To evaluate long-term tumor control and hearing preservation rates in patients with vestibular schwannoma treated with fractionated stereotactic radiotherapy (FSRT), comparing hearing preservation rates to an untreated control group. The relationship between radiation dose to the cochlea and hearing preservation was also investigated.Methods and Materials
Forty-two patients receiving FSRT between 1997 and 2008 with a minimum follow-up of 2 years were included. All patients received 54 Gy in 27-30 fractions during 5.5-6.0 weeks. Clinical and audiometry data were collected prospectively. From a ¡°wait-and-scan¡± group, 409 patients were selected as control subjects, matched by initial audiometric parameters. Radiation dose to the cochlea was measured using the original treatment plan and then related to changes in acoustic parameters.
Results
Actuarial 2-, 4-, and 10-year tumor control rates were 100 % , 91.5 % , and 85.0 % , respectively. Twenty-one patients had serviceable hearing before FSRT, 8 of whom (38 % ) retained serviceable hearing at 2 years after FSRT. No patients retained serviceable hearing after 10 years. At 2 years, hearing preservation rates in the control group were 1.8 times higher compared with the group receiving FSRT (P=.007). Radiation dose to the cochlea was significantly correlated to deterioration of the speech reception threshold (P=.03) but not to discrimination loss.
Conclusion
FSRT accelerates the naturally occurring hearing loss in patients with vestibular schwannoma. Our findings, using fractionation of radiotherapy, parallel results using single-dose radiation. The radiation dose to the cochlea is correlated to hearing loss measured as the speech reception threshold.