Comparative analysis of immunization schedules using a novel adenovirus-based immunotherapeutic targeting hepatitis B in na茂ve and tolerant mouse models
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- 作者：Houda Boukhebzaa ; Clarisse Duboisa ; Vé ; ronique Koerperb ; Alexei Evlacheva ; Yasmine Schlesingerb ; Thierry Menguyb ; Nathalie Silvestreb ; Petra Riedlc ; Geneviè ; ve Inchauspé ; a ; Perrine Martina ; perrine.martin@transgene.fr" class="auth_mail
- 关键词：Ad ; adenovirus ; HBV ; hepatitis B virus ; IFN纬 ; interferon 纬 ; CTL ; cytotoxic T lymphocytes ; ELISPOT ; enzyme-linked immunospot ; ICS ; intracellular cytokine staining ; PD-1 ; programmed cell death-1 ; Sc ; sub-cutaneous ; TNF伪 ; tumor necrosis factor 伪
- 刊名：Vaccine
- 出版年：30 May 2014
- 年：2014
- 卷：32
- 期：26
- 页码：3256-3263
- 全文大小：1848 K
文摘
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Closely spaced administrations of an adenovirus-based HBV immunotherapeutics were explored in naive and HBV mouse models.
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Multiple closely spaced immunizations induced potent HBV specific T cell responses in naïve and HBV tolerant mouse models.
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Multiple closely spaced immunizations induced modulations of induced T cells.
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Multiple closely spaced immunizations do not inhibit induced T cell responses.