A tale of the epidermal growth factor receptor: The quest for structural resolution on cells
详细信息 查看全文
- 作者：Christopher J. Tynan ; Valentina Lo Schiavo ; Laura Zanetti-Domingues ; Sarah R. Needham ; Selene K. Roberts ; Michael Hirsch ; Daniel J. Rolfe ; Dimitrios Korovesis ; David T. Clarke ; Marisa L. Martin-Fernandez ; marisa.martin-fernandez@stfc.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：EGFR ; Membrane protein structure ; Signal transduction ; Receptor tyrosine kinase ; FRET ; Super-resolution microscopy ; Single molecule fluorescence microscopy
- 刊名：Methods
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：86-93
- 全文大小：839 K
文摘
- •
We describe how key concepts in EGFR research have evolved over the preceding decades.
- •
Atomic resolution structures provided by X-ray crystallography provide the basis for understanding EGFR.
- •
Lower resolution microscopy data from receptors in cell membranes often disagrees.
- •
Super-resolution techniques are beginning to bridge the gap between the two.