β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance
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- 作者：Boris Novakovic1 ; 7 ; Ehsan Habibi1 ; 7 ; Shuang-Yin Wang1 ; 7 ; Rob J.W. Arts2 ; Robab Davar1 ; Wout Megchelenbrink1 ; Bowon Kim1 ; Tatyana Kuznetsova1 ; Matthijs Kox3 ; Jelle Zwaag3 ; Filomena Matarese1 ; Simon J. van Heeringen4 ; Eva M. Janssen-Megens1 ; Nilofar Sharifi1 ; Cheng Wang1 ; Farid Keramati1 ; Vivien Schoonenberg1 ; Paul Flicek5 ; Laura Clarke5 ; Peter Pickkers3 ; Simon Heath6 ; Ivo Gut6 ; Mihai G. Netea2 ; Joost H.A. Martens1 ; Colin Logie1 ; Hendrik G. Stunnenberg1 ; 8 ; h.stunnenberg@ncmls.ru.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：epigenome ; transcriptome ; trained innate immunity ; endotoxin tolerance ; histone modifications ; human monocytes ; macrophages ; β-glucan ; lipopolysaccharide ; BLUEPRINT
- 刊名：Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：167
- 期：5
- 页码：1354-1368.e14
- 全文大小：13087 K
文摘
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Epigenetic and transcriptional characterization of human macrophage tolerance
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LPS-exposed monocytes fail to induce macrophage-specific downstream pathways
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Monocyte-induced tolerance of macrophages can be reversed by β-glucan at the epigenetic level
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In-vivo-tolerized monocytes can be reverted to a responsive phenotype ex vivo by β-glucan