Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2)
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- 作者：R.A. Mohameda ; reham.atef@pharma.cu.edu.eg" class="auth_mail" title="E-mail the corresponding author ; A.M. Aghaa ; azzaagha@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; A.A. Abdel-Rahmanb ; abdelrahmana@ecu.edu" class="auth_mail" title="E-mail the corresponding author ; N.N. Nassara ; noha.nassar@pharma.cu.edu.eg" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotropic factor ; cAMP ; cyclic adenosine monophosphate ; CGS21680 ; 3-[4-[2-[[6-amino-9-[(2R ; 3R ; 4S ; 5S)-5-(ethylcarbamoyl)-3 ; 4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid &ndash ; selective adenosine A2A agonist ; Cyt. c ; cytochrome c ; DAG ; diacyl glycerol ; ELT ; escape latency time ; Glu ; glutamate ; IL-10 ; interleukin-10 ; iNOS ; inducible nitric oxide synthase ; IR ; ischemia reperfusion ; MWM ; morris water maze ; NF-κB ; nuclear factor kappa-light-chain-enhancer
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：145-159
- 全文大小：2855 K
文摘
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A2AR activates pERK1/2 in a DAG-dependent pathway in a cerebral IR model.
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SCH58261 protects against cerebral IR by inhibiting pERK1/2 in hippocampal neurons.
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SCH58261 and PD98059 decrease excitotoxicity, inflammatory and apoptotic mediators.