Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways
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- 作者：Huey-Chun Huanga ; lchuang@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chun-Chieh Liaob ; ellis052279@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author ; Chu-Chun Pengb ; chuchun0228@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author ; Jia-Min Limb ; jiajia2008@hotmail.my" class="auth_mail" title="E-mail the corresponding author ; Jen-Hung Siaob ; crazybone917@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author ; Chien-Mei Weib ; flead7889@sunrise.hk.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chien-Chih Chenc ; ccchen@sunrise.hk.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chung-Shing Wud ; 1 ; c686ab@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author ; Tsong-Min Changb ; ctm@sunrise.hk.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ampelopsis grossedentata ; Dihydromyricetin ; Melanogenesis ; Tyrosinase ; Melanin
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 October 2016
- 年：2016
- 卷：258
- 期：Complete
- 页码：166-174
- 全文大小：1709 K
文摘
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Dihydromyricetin inhibits melanogenesis in B16F10 melanoma cells.
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Dihydromyricetin decreases the expressions of MC1R, MITF and TRP-1.
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Dihydromyricetin effectively decreases intracellular ROS and RS levels.
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Dihydromyricetin downregulates MAPK, PKA and PKC pathways.