Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome
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- 作者：J. Luis Olmos-Serranoa ; lolmos@bu.edu" class="auth_mail" title="E-mail the corresponding author ; William A. Tylera ; wtyler@bu.edu" class="auth_mail" title="E-mail the corresponding author ; Howard J. Cabralb ; hjcab@bu.edu" class="auth_mail" title="E-mail the corresponding author ; Tarik F. Haydara ; thaydar@bu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Down syndrome ; Ts65Dn ; Mouse model ; Cognition ; Aging ; Reversal learning ; Mouse behavior ; Developmental disorder ; Developmental milestones ; Alzheimer Disease
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：279
- 期：Complete
- 页码：40-56
- 全文大小：2486 K
文摘
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Naïve learning impairment g in Ts65Dn is affected by thigmotaxis.
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Impairment in reversal learning is a major feature of Ts65Dn cognitive function.
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Delays in developmental milestones predict adult behavioral function.
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Reversal learning is impacted with age in Ts65Dn and controls.
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Individual behavioral performance uncovers heterogeneity within both genotypes.