Estrogen receptor variant ER-α36 is involved in estrogen neuroprotection against oxidative toxicity
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- 作者：S. Hana ; hanshuaifei1987@163.com" class="auth_mail" title="E-mail the corresponding author ; B. Zhaoa ; 472946565@qq.com" class="auth_mail" title="E-mail the corresponding author ; X. Panb ; pxh1997@126.com" class="auth_mail" title="E-mail the corresponding author ; Z. Songa ; 15169193767@163.com" class="auth_mail" title="E-mail the corresponding author ; J. Liua ; lzp90715@163.com" class="auth_mail" title="E-mail the corresponding author ; Y. Gonga ; yxg8@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; M. Wanga ; wml@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; BCA ; bicinchoninic acid ; DMEM/F12 ; Dulbecco&rsquo ; s modified eagle&rsquo ; s medium/nutrient mixture F-12 ; DMSO ; dimethyl sulfoxide ; E2β ; 17β-estradiol ; ECL ; enhanced chemiluminescence ; ER ; estrogen receptor ; FBS ; fetal bovine serum ; FITC ; fluorescein isothiocyanate ; GPER ; G protein&ndash ; coupled receptor ; H2O2 ; hydrogen peroxide ; MTT ; 3-(4 ; 5-cimethylthiazol-2-yl)-2 ; 5-diphenyl tetrazolium bromide ; PI ; propidium iodide ; PVDF ; polyvinylidene fluoride ; siRNA ; small inte
- 刊名：Neuroscience
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：310
- 期：Complete
- 页码：224-241
- 全文大小：4690 K
文摘
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ER-α36 is involved in estrogen neuroprotection.
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ER-α36 is involved in rapid activation of the PI3K/AKT and MAPK/ERK signaling pathways in estrogen neuroprotective effect.
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GPER (GPR30) is not involved in ER-α36-mediated rapid estrogen response.