Synthesis and evaluation of Lys1(α,γ-Folate)Lys3(177Lu-DOTA)-Bombesin(1-14) as a potential theranostic radiopharmaceutical for breast cancer
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- 作者：Liliana Aranda-Laraa ; b ; Guillermina Ferro-Floresa ; ferro_flores@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author ; guillermina.ferro@inin.gob.mx" class="auth_mail" title="E-mail the corresponding author ; Erika Azorí ; n-Vegaa ; Flor de Marí ; a Ramí ; reza ; Nallely Jimé ; nez-Mancillac ; Blanca Ocampo-Garcí ; aa ; Clara Santos-Cuevasa ; Keila Isaac-Olivé ; b
- 关键词：Lutetium-177 ; Theranostic radiopharmaceuticals ; Theterobivalent molecules ; Breast cancer
- 刊名：Applied Radiation and Isotopes
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：214-219
- 全文大小：888 K
文摘
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177Lu-Folate-BN improves recognition of breast cancer cells positive to FR and GRPR.
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177Lu-Folate-BN shows theranostic (imaging and radiation therapy) properties.
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The heterobivalent 177Lu-Folate-BN tracer interacts with different targets on tumors.