Accessory respiratory muscles enhance ventilation in ALS model mice and are activated by excitatory V2a neurons
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- 作者：Shannon H. Romera ; Kari Seedlea ; Sarah M. Turnera ; Jie Lic ; Mark L. Bacceic ; Steven A. Cronea ; b ; Steven.Crone@cchmc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALS ; Amyotrophic Lateral Sclerosis ; ARM ; Accessory Respiratory Muscle ; EMG ; Electromyography ; mRF ; Medial Reticular Formation ; WBP ; Whole Body Plethysmography ; SOD1 ; Superoxide Dismutase 1 ; PIF ; Peak Inspiratory Flow ; TV ; Tidal Volume ; MV ; Minute Volume
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P2
- 页码：192-204
- 全文大小：1954 K
文摘
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Accessory respiratory muscles are recruited early in disease in a mouse model of ALS
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Accessory muscles are functional but not used for breathing at late disease stages
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V2a neurons are sufficient to drive accessory respiratory muscle activity
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V2a neurons degenerate in mouse models of ALS