Predicting promiscuous antigenic T cell epitopes of Mycobacterium tuberculosis mymA operon proteins binding to MHC Class I and Class II molecules
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- 作者：Iti Saraava ; etisaraav@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kirti Pandeya ; kirti.pandey5@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Monika Sharmaa ; monikasharma.mh@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Swati Singha ; singhswati.mh@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Prasun Duttab ; prasundutta87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Anshu Bhardwajb ; anshu@csir.res.in" class="auth_mail" title="E-mail the corresponding author ; Sadhna Sharmaa ; sadhna.sharma@mirandahouse.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antigenic T-cell epitopes ; Mycobacterium tuberculosis ; mymA operon ; Tuberculosis ; Vaccine candidates
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：182-189
- 全文大小：1080 K
文摘
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Potential T cell epitopes of mymA operon proteins capable of binding to MHC Class I and Class II alleles were identified.
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Of mymA operon proteins Rv3083 was found to be the best vaccine candidate.
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Molecular docking was performed with most promiscuous and antigenic epitopes of Rv3083 with MHC Class I and II molecules.
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The software binding prediction was validated by the obtained molecular docking score of peptide-HLA complex.