Genomic structure and expression pattern of MHC IIα and IIβ genes reveal an unusual immune trait in lined seahorse Hippocampus erectus
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- 作者：Wei Luoa ; Xin Wanga ; b ; Hongyue Qua ; b ; Geng Qina ; Huixian Zhanga ; Qiang Lina ; linqiangzsu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Major histocompatibility complex II ; Polymorphism ; Genomic structure ; Selective pressure ; Hippocampus erectus
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：521-529
- 全文大小：1295 K
文摘
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Only one gene copy number of MHC IIα and IIβ genes were found in the lined seahorse.
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The seahorse had MHC IIα and IIβ genes, but the pipefish, a close relative in evolution, lacked them.
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High expression of MHC II was detected in the muscle and brood pouch.
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A challenge test demonstrated the muscle and brood pouch are sensitive and important for the MHC-mediated immune response.