Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism
详细信息 查看全文
- 作者：Philip M. Proberta ; Jeremy M. Palmera ; Wasma Alhusainyb ; Aimen O. Amera ; Ivonne M.C.M. Rietjensb ; Steven A. Whitea ; David E. Jonesa ; Matthew C. Wrighta ; M.C.Wright@ncl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP ; cytochrome P450s ; DEX ; dexamethasone ; E-3&prime ; -N2-dGuo ; N2-(trans-isoestragol-3&prime ; -yl)-2&prime ; -deoxyguanosine ; GSTs ; glutathione S transferases ; OTM ; olive tail moment ; PAPSS ; 3&prime ; -phosphoadenosine 5&prime ; -phosphosulphate synthase ; PCP ; pentachlorophenol ; PNP ; ρ-nitrophenol ; SULT ; sulphotransferase ; UDPGTs ; UDP-glucuronyl transferases
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：243
- 期：Complete
- 页码：98-110
- 全文大小：3051 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
B-13/H cells are null for functional SULT1A1 but express functional SULT2B1 activity.
- class="label">•
B-13/H cells activate 1′ hydroxyestragole to a genotoxic metabolite.
- class="label">•
SULT2B1 is expressed in cholangiocytes in rat and human liver.
- class="label">•
B-13/H cells express a cholangiocyte pattern of sulphotransferase (SULT) expression.
- class="label">•
Tumours in estragole-exposed rats may be dependent on cholangiocyte SULT2B1.