Frequency and treatment of depressive symptoms in a Parkinson's disease registry

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• 作者：Astrid Althaus ; Oliver Arrá ; nz Becker ; Annika Spottke ; Reinhard Dengler ; Frank Schneider ; Manja Kloss ; Karla Eggert ; Wolfgang H. Oertel ; Ulrich Dillmann ; Birgit Herting ; Joseph Classen ; Richard Do
• 关键词：Parkinson's disease ; Depression ; Antidepressants ; MADRS
• 刊名：Parkinsonism and Related Disorders
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：14
• 期：8
• 页码：626-632
• 全文大小：176 K

文摘

Purpose of this cross-sectional study was to estimate the occurrence of depressive symptoms, as related to other clinical data, in a sample of Parkinson's disease (PD) patients (n = 226). Furthermore, we examined the medical care of depressive symptoms in this sample.

H&Y stages, cognitive status, sleeping disorders, and dysphagia resulted as significant predictors for depression. Prevalence of depressive symptoms was 35.4 % . Only 25.0 % of patients suffering from moderate to severe depressive symptoms were prescribed antidepressants.

This study supports the view that depression may be underrecognized and undertreated in PD patients. A significant proportion of patients continues to experience depressive symptoms despite antidepressive medication. Recognition and treatment of depression remains a challenge for management of PD. Possible coexisting depressive symptoms should be revealed and assessed by standardized interviews in everyday clinical routine. Large scale randomized controlled trials examining efficacy and safety of antidepressants in PD patients are urgently required.