The biphosphinic paladacycle complex induces melanoma cell death through lysosomal-mitochondrial axis modulation and impaired autophagy
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- 作者：Rafael Giglia ; Gustavo J.S. Pereiraa ; Fernanda Antunesa ; Alexandre Becharaa ; Daniel M. Garciaa ; Daniel G. Spindolaa ; Mirian G. Jasiulionisa ; Antonio C.F. Cairesb ; &dagger ; ; Soraya S. Smailia ; Claudia Bincolettoa ; claudia.bincoletto@unifesp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Autophagy ; Lysosome-mitochondria axis ; Cyclopalladated complex ; Melanoma cells
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：245-254
- 全文大小：2314 K
文摘
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BPC11 induces LMP with release of CatB from lysosome to cytosol.
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Bax is translocated to mitochondria, resulting in ↓ ΔΨm and cleaved caspase-3;.
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BPC11 increases LC3II and p62 protein levels, suggesting autophagy impairment.
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Inhibition of autophagy seems to enhance the anti-melanoma effects of BPC11;
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Finally BPC11 induces both (Tm5 and 4C11-) cell death in a similar way.