Altered Editing of Serotonin 2C Receptor Pre-mRNA in the Prefrontal Cortex of Depressed Suicide Victims

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• 作者：Ilona Gurevich ; Hadassah Tamir ; Victoria Arango ; Andrew J. Dwork ; J. John Mann and Claudia Schmauss
• 刊名：Neuron
• 出版年：2002
• 出版时间：25 April 2002
• 年：2002
• 卷：34
• 期：3
• 页码：349-356
• 全文大小：209 K

文摘

Five adenosines within the coding sequence of the serotonin 2C receptor (5-HT2C) pre-mRNA are converted to inosines by RNA editing (named A, B, C′ (E), C, and D sites). In human prefrontal cortex (PFC), the most abundant 5-HT2C mRNA sequences result from editing at the A site, or from the editing combinations AC′C, ABCD, and ABD. In suicide victims with a history of major depression, C′ site editing is significantly increased, D site editing is significantly decreased, and the C site shows a trend toward increased editing. Treatment of mice with the antidepressant drug fluoxetine (Prozac™) causes changes in C′, C, and D site editing that are exactly opposite to those seen in suicide victims. Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims.