Clavulanic acid separation on fixed bed columns of layered double hydroxides: Optimization of operating parameters using breakthrough curves
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- 作者：Marcus Bruno Soares Fortea ; marcusbsforte@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Christine Taviot-Gué ; hob ; c ; Fabrice Lerouxb ; c ; Maria Isabel Rodriguesa ; Francisco Maugeri Filhoa
- 关键词：Clavulanic acid ; Layered double hydroxides ; Adsorption ; Separation ; Purification ; Fixed bed ; Breakthrough curves ; Factorial design
- 刊名：Process Biochemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：51
- 期：4
- 页码：509-516
- 全文大小：1063 K
文摘
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Adsorption breakthrough curves of CA in a fixed-bed column of LDHME adsorbents.
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Response surfaces enabled identification of the best column operating conditions.
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Factorial design technique is an efficient tool for process optimization.
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Good separation of CA from the amino acids tyrosine and proline was observed.
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The LDHME adsorbent was shown to be an excellent alternative for CA purification.